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Any sleep issues that become problematic should be more closely investigated as to what factors may be at the root of the problem

Further, a more than two-fold increase in the duration of base rigidity at or above 60% was observed when comparing the response of individual patients to PT-141 versus placebo [15]

| Ohio State Medical Center - YouTube, accessed April 21, 2025, Study identifies 3 strategies to minimize muscle loss from GLP-1 weight loss drugs, accessed April 21, 2025, pmc.ncbi.nlm.nih.gov, accessed April 21, 2025, GLP1 receptor agonists for the treatment of obesity: Role as a promising approach, accessed April 21, 2025, Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists - Frontiers, accessed April 21, 2025, Effects of Weight Loss on Lean Mass, Strength, Bone, and Aerobic Capacity - PMC, accessed April 21, 2025, Preserving Healthy Muscle during Weight Loss - PMC, accessed April 21, 2025, Boosting BCL6 may counteract muscle loss from GLP-1 medications, accessed April 21, 2025, Muscle Loss and GLP-1s: Why It Matters and How To Address It - Vori Health, accessed April 21, 2025, Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies - PubMed, accessed April 21, 2025, Semaglutide and GLP-1: Effects on lean body mass still unclear, accessed April 21, 2025, Normative vs Excess Muscle Loss and Strength with GLP-1 Medications vs Other Weight Loss Methods - Ro, accessed April 21, 2025, Does Ozempic cause muscle loss and how to prevent it

Multi-use vial (up to 28 days after first puncture if handled properly)

Granulation tissue removal in routine and minimally invasive procedures